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UKMLB Opening Day Odds & Picks (2025)
Spring is in the air and MLB Opening Day odds are live—it’s time to cash in on the biggest matchups of the season opener. Coming off a wild offseason filled with high-profile free agent moves and some surprising roster shake-ups, we’ve got the inside scoop on MLB Opening Day 2025.
From the best bets to potential Opening Day upsets, let’s break down our bold predictions to kick off the MLB season.
Odds for MLB Opening Day 2025
This year’s Opening Day is set for March 27 and baseball bettors are in for a treat with 14 games scheduled to kick off the regular season.
All of the betting odds shown below are from Bovada Sportsbook, giving you the latest lines on every MLB matchup so you know exactly where to put your money on Opening Day.
| RoadTeam | Road Team Moneyline Odds | HomeTeam | Home Team Moneyline Odds |
|---|---|---|---|
| Milwaukee Brewers | +142 | New York Yankees | -172 |
| Baltimore Orioles | -120 | Toronto Blue Jays | +100 |
| Boston Red Sox | -105 | Texas Rangers | -115 |
| Philadelphia Phillies | -185 | Washington Nationals | +153 |
| Atlanta Braves | -123 | San Diego Padres | +103 |
| Cleveland Guardians | +114 | Kansas City Royals | -136 |
| Los Angeles Angels | -149 | Chicago White Sox | +125 |
| New York Mets | +105 | Houston Astros | -125 |
| Pittsburgh Pirates | -163 | Miami Marlins | +137 |
| San Francisco Giants | +105 | Cincinnati Reds | -125 |
| Minnesota Twins | -118 | St. Louis Cardinals | -102 |
| Detroit Tigers | +139 | Los Angeles Dodgers | -165 |
| Chicago Cubs | +142 | Arizona Diamondbacks | -172 |
| Athletics | +145 | Seattle Mariners | -177 |
With MLB Opening Day just around the corner, it’s time to unpack the latest odds and find the best bets to kick off the season. If you like following the trends when betting on baseball, it’s worth noting that since 1999, the Orioles boast the best Opening Day record at 19-7.
The Mets are intriguing Opening Day betting option, as they’re listed as underdogs despite landing Juan Soto on a staggering $765 million deal this offseason. If all else fails, you can always try fading the White Sox, who are coming off a historically bad 121-loss campaign.
Not sure where to bet on Opening Day? Try Bovada!
Best Site for Betting on MLB Opening Day Bovada Sportsbook
Want to make the most of your MLB Opening Day bets this season? Bovada knocks it out of the park with consistently competitive odds, early lines and an impressive range of props and futures to keep things interesting. It’s the smart choice for Opening Day action.
New bettors can take advantage of their generous welcome bonus, while existing players can bolster their bankroll with Bovada’s rewards program and parlay boosters. With their user-friendly platform, live odds and smooth mobile betting, Bovada is one of the top betting sites for MLB Opening Day.
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This score goes to the highest rated sites by experts. Only sites that hold an expert rating of above 85% are given this status.
A green Jackpot Certified score is awarded when at least 60% of expert reviews are positive.
A red Bust score is displayed when less than 60% of expert reviews are positive.
A grayed-out gem means there are not enough expert ratings to produce a score. The gambling site could be new.
A green Jackpot Certified score means that at least 60% of player reviews are positive.
A red Bust score means that less that 59% or less of player reviews are positive.
A grayed-out face means there are not enough player reviews to produce a score.
Best Bets for 2025 Opening Day
MLB Opening Day odds can be tough to get a read on, but a few matchups stand out as prime betting opportunities. Here are our top picks to kick off the season.
Top Opening Day Upset Picks
Finding betting value on MLB Opening Day means spotting the underdogs that are ready to surprise. Here are our best upset picks to get your baseball season started with a bang.
2025 MLB Opening Day Predictions
Baseball’s back, and so are the betting lines—let’s check out our MLB Opening Day predictions and get you in on the betting action.
The teams bolded below are the ones we predict will come out on top, so keep an eye on those squads when placing your bets.
| Road Team | Home Team |
|---|---|
| Milwaukee Brewers | New York Yankees |
| Baltimore Orioles | Toronto Blue Jays |
| Boston Red Sox | Texas Rangers |
| Philadelphia Phillies | Washington Nationals |
| Atlanta Braves | San Diego Padres |
| Cleveland Guardians | Kansas City Royals |
| Los Angeles Angels | Chicago White Sox |
| New York Mets | Houston Astros |
| Pittsburgh Pirates | Miami Marlins |
| San Francisco Giants | Cincinnati Reds |
| Minnesota Twins | St. Louis Cardinals |
| Detroit Tigers | Los Angeles Dodgers |
| Chicago Cubs | Arizona Diamondbacks |
| Athletics | Seattle Mariners |
Betting on MLB Opening Day 2025
Opening Day is the perfect time to cash in on some betting value and our top pick has to be the Seattle Mariners -177 over the Athletics. With ace Luis Castillo on the mound and the Seattle home crowd behind them, it’s a solid play to start the season.
When you’re ready to lock in your Opening Day bets, head to Bovada for the best odds and tons of fun MLB props. Let’s get this baseball season started with some winning plays!
