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UKMLB Opening Day Odds & Picks (2025)
Spring is in the air and MLB Opening Day odds are live—it’s time to cash in on the biggest matchups of the season opener. Coming off a wild offseason filled with high-profile free agent moves and some surprising roster shake-ups, we’ve got the inside scoop on MLB Opening Day 2025.
From the best bets to potential Opening Day upsets, let’s break down our bold predictions to kick off the MLB season.
Odds for MLB Opening Day 2025
This year’s Opening Day is set for March 27 and baseball bettors are in for a treat with 14 games scheduled to kick off the regular season.
All of the betting odds shown below are from Bovada Sportsbook, giving you the latest lines on every MLB matchup so you know exactly where to put your money on Opening Day.
| RoadTeam | Road Team Moneyline Odds | HomeTeam | Home Team Moneyline Odds |
|---|---|---|---|
| Milwaukee Brewers | +142 | New York Yankees | -172 |
| Baltimore Orioles | -120 | Toronto Blue Jays | +100 |
| Boston Red Sox | -105 | Texas Rangers | -115 |
| Philadelphia Phillies | -185 | Washington Nationals | +153 |
| Atlanta Braves | -123 | San Diego Padres | +103 |
| Cleveland Guardians | +114 | Kansas City Royals | -136 |
| Los Angeles Angels | -149 | Chicago White Sox | +125 |
| New York Mets | +105 | Houston Astros | -125 |
| Pittsburgh Pirates | -163 | Miami Marlins | +137 |
| San Francisco Giants | +105 | Cincinnati Reds | -125 |
| Minnesota Twins | -118 | St. Louis Cardinals | -102 |
| Detroit Tigers | +139 | Los Angeles Dodgers | -165 |
| Chicago Cubs | +142 | Arizona Diamondbacks | -172 |
| Athletics | +145 | Seattle Mariners | -177 |
With MLB Opening Day just around the corner, it’s time to unpack the latest odds and find the best bets to kick off the season. If you like following the trends when betting on baseball, it’s worth noting that since 1999, the Orioles boast the best Opening Day record at 19-7.
The Mets are intriguing Opening Day betting option, as they’re listed as underdogs despite landing Juan Soto on a staggering $765 million deal this offseason. If all else fails, you can always try fading the White Sox, who are coming off a historically bad 121-loss campaign.
Not sure where to bet on Opening Day? Try Bovada!
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Best Bets for 2025 Opening Day
MLB Opening Day odds can be tough to get a read on, but a few matchups stand out as prime betting opportunities. Here are our top picks to kick off the season.
Baltimore Orioles -120 (vs. Toronto Blue Jays) – BET NOW
The Orioles are coming off a 91-win season with a young, talented roster looking to take the next step in a competitive AL East. Their pitching might not be elite, but their bats should be able to carry them over a Toronto squad that struggles with secondary scoring.
Arizona Diamondbacks -172 (vs. Chicago Cubs) – BET NOW
The Diamondbacks missed the playoffs last season, but this team is only two years removed from winning the pennant. They also loaded up during the offseason with starting pitcher Corbin Burnes and Josh Naylor at first base. Meanwhile, the Cubs’ lineup is full of question marks and they’re already 0-2 after losing twice to the Dodgers in Japan.
Seattle Mariners -177 (vs. Athletics) – BET NOW
We’re all over the Mariners at -177 against the A’s. The game is in Seattle and that Opening Day crowd energy is a major boost. Plus, Luis Castillo is on the mound, and he’s a legit ace. Oakland’s brutal on Opening Day too—just 9 wins in 25 years. Easy call to bet Seattle here.
Top Opening Day Upset Picks
Finding betting value on MLB Opening Day means spotting the underdogs that are ready to surprise. Here are our best upset picks to get your baseball season started with a bang.
San Diego Padres +103 (vs. Atlanta Braves) – BET NOW
The Padres are coming off a 93-win season—their second-best ever—and they’re hungry to bounce back after a rough postseason exit. The Braves are no pushover, but with Michael King on the mound and Fernando Tatis Jr. healthy, their lineup is stacked with star power and ready to go.
New York Mets +105 (vs. Houston Astros) – BET NOW
Mets fans are buzzing after landing Juan Soto in free agency, and with Pete Alonso and Sean Manaea back, they’re looking like legit World Series contenders. Meanwhile, the Astros lost some pop with Kyle Tucker and Alex Bregman gone. New York could pull off the Opening Day upset in this one.
Detroit Tigers +139 (vs. Los Angeles Dodgers) – BET NOW
Betting against the Dodgers might seem risky, but there’s plenty to like about this year’s Tigers. Detroit’s coming off an exciting playoff run last summer and their young talent is finally breaking through. Plus, the Dodgers could be a bit jet-lagged after just flying back from Japan. At +139, it’s worth a shot.
2025 MLB Opening Day Predictions
Baseball’s back, and so are the betting lines—let’s check out our MLB Opening Day predictions and get you in on the betting action.
The teams bolded below are the ones we predict will come out on top, so keep an eye on those squads when placing your bets.
| Road Team | Home Team |
|---|---|
| Milwaukee Brewers | New York Yankees |
| Baltimore Orioles | Toronto Blue Jays |
| Boston Red Sox | Texas Rangers |
| Philadelphia Phillies | Washington Nationals |
| Atlanta Braves | San Diego Padres |
| Cleveland Guardians | Kansas City Royals |
| Los Angeles Angels | Chicago White Sox |
| New York Mets | Houston Astros |
| Pittsburgh Pirates | Miami Marlins |
| San Francisco Giants | Cincinnati Reds |
| Minnesota Twins | St. Louis Cardinals |
| Detroit Tigers | Los Angeles Dodgers |
| Chicago Cubs | Arizona Diamondbacks |
| Athletics | Seattle Mariners |
Betting on MLB Opening Day 2025
Opening Day is the perfect time to cash in on some betting value and our top pick has to be the Seattle Mariners -177 over the Athletics. With ace Luis Castillo on the mound and the Seattle home crowd behind them, it’s a solid play to start the season.
When you’re ready to lock in your Opening Day bets, head to Bovada for the best odds and tons of fun MLB props. Let’s get this baseball season started with some winning plays!
